N-end rule
id:
n-end-rule-254-7249279
title:
N-end rule
text:
The N-end rule is a rule that governs the rate of protein degradation through recognition of the N-terminal residue of proteins. The rule states that the N-terminal amino acid of a protein determines its half-life. The rule applies to both eukaryotic and prokaryotic organisms, but with different strength, rules, and outcome. In eukaryotic cells, these N-terminal residues are recognized and targeted by ubiquitin ligases, mediating ubiquitination thereby marking the protein for degradation. The ru
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/N-end_rule
date created:
date modified:
2023-12-02T18:12:31Z
main entity:
{"identifier":"Q3491438","url":"https://www.wikidata.org/entity/Q3491438"}
image:
fields total:
13
integrity:
13