MG132
id:
mg132-205-15450457
title:
MG132
text:
MG132 is a potent, reversible, and cell-permeable proteasome inhibitor. It belongs to the class of synthetic peptide aldehydes. It reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. MG132 also inhibits NF-κB activation with an IC50 of 3 μM and prevents β-secretase cleavage.
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/MG132
date created:
2009-02-13T04:06:08Z
date modified:
2024-09-10T11:11:36Z
main entity:
{"identifier":"Q3272916","url":"https://www.wikidata.org/entity/Q3272916"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/c/c8/MG132.svg","width":512,"height":235}
fields total:
13
integrity:
16