ZMPSTE24
id:
zmpste24-285-17520912
title:
ZMPSTE24
text:
ZMPSTE24 is a human gene. The protein encoded by this gene is a metallopeptidase. It is involved in the processing of lamin A. Defects in the ZMPSTE24 gene lead to similar laminopathies as defects in lamin A, because the latter is a substrate for the former. In humans, a mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder. Failure to correctly process prelamin A leads to deficient ability to repair DNA double-strand breaks. As shown by Liu et al., lack of Zmp
brand slug:
wiki
category slug:
encyclopedia
description:
Protein-coding gene in the species Homo sapiens
original url:
https://en.wikipedia.org/wiki/ZMPSTE24
date created:
date modified:
2023-03-03T20:55:25Z
main entity:
{"identifier":"Q1022703","url":"https://www.wikidata.org/entity/Q1022703"}
image:
fields total:
13
integrity:
14