Viral infectivity factor
id:
viral-infectivity-factor-161-9595915
title:
Viral infectivity factor
text:
Viral infectivity factor, or Vif, is an accessory protein found in HIV and other lentiviruses. Its role is to disrupt the antiviral activity of the human enzyme APOBEC by targeting it for ubiquitination and cellular degradation. APOBEC is a cytidine deaminase enzyme that mutates viral nucleic acids. Despite the functional and (weak) structural similarities, Vif found in lentiviruses can function in quite different ways. For example, the HIV-1 Vif and HIV-2 Vif ("Vif2") attach to APOBEC from diff
brand slug:
wiki
category slug:
encyclopedia
description:
Protein found in lentiviruses
original url:
https://en.wikipedia.org/wiki/Viral_infectivity_factor
date created:
2005-11-02T20:53:54Z
date modified:
2024-08-27T07:28:29Z
main entity:
{"identifier":"Q4011523","url":"https://www.wikidata.org/entity/Q4011523"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/3/33/Crystal_Structure_of_the_HIV_Vif_BC-box_in_Complex_with_Human_ElonginB_and_ElonginC.png","width":640,"height":480}
fields total:
13
integrity:
16