Vilsmeier–Haack reaction
id:
vilsmeier-haack-reaction-162-16104596
title:
Vilsmeier–Haack reaction
text:
The Vilsmeier–Haack reaction is the chemical reaction of a substituted formamide (1) with phosphorus oxychloride and an electron-rich arene (3) to produce an aryl aldehyde or ketone (5):
- RC(=O)NR′R″ + HArZ + POCl3 + H2O → RC(=O)ArZ + NR′R″H + HCl + H3PO4 The reaction is named after Anton Vilsmeier and Albrecht Haack. For example, benzanilide and dimethylaniline react with phosphorus oxychloride to produce an unsymmetrical diaryl ketone. Similarly, anthracene is formylated at the 9-position.
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical reaction
original url:
https://en.wikipedia.org/wiki/Vilsmeier%E2%80%93Haack_reaction
date created:
2005-08-09T21:16:04Z
date modified:
2024-08-28T02:08:11Z
main entity:
{"identifier":"Q903038","url":"https://www.wikidata.org/entity/Q903038"}
image:
fields total:
13
integrity:
15