Thymidylate synthase inhibitor
id:
thymidylate-synthase-inhibitor-238-8617459
title:
Thymidylate synthase inhibitor
text:
Thymidylate synthase inhibitors are chemical agents which inhibit the enzyme thymidylate synthase and have potential as an anticancer chemotherapy. This inhibition prevents the methylation of C5 of deoxyuridine monophosphate (dUMP) thereby inhibiting the synthesis of deoxythymidine monophosphate (dTMP). The downstream effect is promotion of cell death because cells would not be able to properly undergo DNA synthesis if they are lacking dTMP, a necessary precursor to dTTP.
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brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Thymidylate_synthase_inhibitor
date created:
date modified:
2024-04-22T10:51:24Z
main entity:
{"identifier":"Q7799629","url":"https://www.wikidata.org/entity/Q7799629"}
image:
fields total:
13
integrity:
13