T790M
id:
t790m-301-10579179
title:
T790M
text:
T790M, also known as Thr790Met, is a gatekeeper mutation of the epidermal growth factor receptor (EGFR). The mutation substitutes a threonine (T) with a methionine (M) at position 790 of exon 20, affecting the ATP binding pocket of the EGFR kinase domain. Threonine is a small polar amino acid; methionine is a larger nonpolar amino acid. Rather than directly blocking inhibitor binding to the active site, T790M increases the affinity for ATP so that the inhibitors are outcompeted; irreversible cov
brand slug:
wiki
category slug:
encyclopedia
description:
Genetic variant
original url:
https://en.wikipedia.org/wiki/T790M
date created:
date modified:
2024-04-06T03:33:49Z
main entity:
{"identifier":"Q25100112","url":"https://www.wikidata.org/entity/Q25100112"}
image:
fields total:
13
integrity:
14