Spinal and bulbar muscular atrophy
id:
spinal-and-bulbar-muscular-atrophy-285-4799774
title:
Spinal and bulbar muscular atrophy
text:
Spinal and bulbar muscular atrophy (SBMA), popularly known as Kennedy's disease, is a rare, adult-onset, X-linked recessive lower motor neuron disease caused by trinucleotide CAG repeat expansions in exon 1 of the androgen receptor (AR) gene, which results in both loss of AR function and toxic gain of function. In men, the disease slowly progresses over decades with bulbar and lower motor neuron loss, muscle denervation, and direct skeletal muscle involvement. The disease causes progressive mus
brand slug:
wiki
category slug:
encyclopedia
description:
Medical condition
original url:
https://en.wikipedia.org/wiki/Spinal_and_bulbar_muscular_atrophy
date created:
date modified:
2023-11-08T01:14:31Z
main entity:
{"identifier":"Q1995327","url":"https://www.wikidata.org/entity/Q1995327"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/3/3c/Impacts_of_SBMA2.svg","width":450,"height":495}
fields total:
13
integrity:
15