Spi-1 (PU.1) 5′ UTR regulatory element
id:
spi-1-pu-1-5-utr-regulatory-element-299-9988564
title:
Spi-1 (PU.1) 5′ UTR regulatory element
text:
The Spi-1 (PU.1) 5′ UTR regulatory element is an RNA element found in the 5′ UTR of Spi-1 mRNA which is able to inhibit the translation Spi-1 transcripts by 8-fold. Spi-1 regulates myeloid gene expression during haemopoietic development. Mutations in this regulatory region of the 5′ UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia.
brand slug:
wiki
category slug:
encyclopedia
description:
RNA element in Spi-1 mRNA
original url:
https://en.wikipedia.org/wiki/Spi-1_(PU.1)_5%E2%80%B2_UTR_regulatory_element
date created:
date modified:
2023-05-14T07:29:01Z
main entity:
{"identifier":"Q7576852","url":"https://www.wikidata.org/entity/Q7576852"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/8/86/RF00232.jpg","width":452,"height":452}
fields total:
13
integrity:
15