SN-38
id:
sn-38-200-983162
title:
SN-38
text:
SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold. SN38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1. The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolism of SN-38 predicts irinotecan toxicity, as it is then less easily excr
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/SN-38
date created:
date modified:
2024-01-11T16:48:43Z
main entity:
{"identifier":"Q1750127","url":"https://www.wikidata.org/entity/Q1750127"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/b/b6/SN-38.svg","width":1411,"height":990}
fields total:
13
integrity:
15