Selective inhibitor of nuclear export
id:
selective-inhibitor-of-nuclear-export-288-17981875
title:
Selective inhibitor of nuclear export
text:
Selective inhibitors of nuclear export are drugs that block exportin 1, a protein involved in transport from the cell nucleus to the cytoplasm. This causes cell cycle arrest and cell death by apoptosis. Thus, SINE compounds are of interest as anticancer drugs; several are in development, and one (selinexor) has been approved for treatment of multiple myeloma as a drug of last resort. The prototypical nuclear export inhibitor is leptomycin B, a natural product and secondary metabolite of Streptom
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Selective_inhibitor_of_nuclear_export
date created:
date modified:
2023-09-17T14:47:43Z
main entity:
{"identifier":"Q65122840","url":"https://www.wikidata.org/entity/Q65122840"}
image:
fields total:
13
integrity:
13