SCH-48461
id:
sch-48461-319-15826149
title:
SCH-48461
text:
SCH-48461 is a cholesterol absorption inhibitor. During the early phases of an NPC1L1 inhibitor discovery program at Schering-Plough, conformationally restricted analogs based on the 2-azetidinone backbone were targeted by Burnett and co-workers. Early in the biological evaluation, it became apparent that even though the in vitro ACAT inhibitory activity of these analogs was modest (e.g., IC50 values of 2–50 mM), they exhibited significant activity in a cholesterol-fed hamster model (CFH). The d
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/SCH-48461
date created:
date modified:
2021-05-04T02:50:59Z
main entity:
{"identifier":"Q7389138","url":"https://www.wikidata.org/entity/Q7389138"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/c/c8/SCH-48461.svg","width":512,"height":370}
fields total:
13
integrity:
15