Runt domain
id:
runt-domain-288-12214591
title:
Runt domain
text:
The Runt domain is an evolutionary conserved protein domain. The AML1/RUNX1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction. In addition to the highly conserved Runt domain, the AML-1 gene product carries a
brand slug:
wiki
category slug:
encyclopedia
description:
Evolutionary conserved protein domain
original url:
https://en.wikipedia.org/wiki/Runt_domain
date created:
date modified:
2023-07-02T18:43:37Z
main entity:
{"identifier":"Q24771277","url":"https://www.wikidata.org/entity/Q24771277"}
image:
fields total:
13
integrity:
14