Quasi-irreversible inhibitor
id:
quasi-irreversible-inhibitor-286-4478683
title:
Quasi-irreversible inhibitor
text:
For acetylcholinesterase (AChE), quasi-irreversible inhibitors are those that rapidly phosphorylate AChE. A subsequent internal dealkylation reaction may then occur, which, according to X-ray crystallography data, is suggestive of covalent bond formation. The newly formed OP-enzyme conjugate is as a result permanently deactivated. Historically, irreversible acetylcholinesterase inhibitors have been used as insecticides and chemical weapons.
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Quasi-irreversible_inhibitor
date created:
date modified:
2021-11-14T22:05:57Z
main entity:
{"identifier":"Q7269456","url":"https://www.wikidata.org/entity/Q7269456"}
image:
fields total:
13
integrity:
13