PUGNAc
id:
pugnac-265-3170471
title:
PUGNAc
text:
PUGNAc is a 1,5-hydroximolactone, acting as an inhibitor of a variety of N-acetylhexosaminidases. It was long thought that increased levels of O-GlcNAc in human cells lead to Type II diabetes. O-GlcNAc levels were artificially raised with PUGNAc, which inhibits O-GlcNAcase, a beta-exo-N-acetylhexosaminidase which cleaves beta-O-linked-N-acetylglucosamine residues from glycoproteins. As a result of this inhibition, a type II diabetic phenotype was observed. Recent pharmacological studies using a
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/PUGNAc
date created:
date modified:
2024-03-25T04:24:54Z
main entity:
{"identifier":"Q7121081","url":"https://www.wikidata.org/entity/Q7121081"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/6/60/Pugnac.png","width":2904,"height":1389}
fields total:
13
integrity:
15