Prexasertib
id:
prexasertib-295-18127287
title:
Prexasertib
text:
Prexasertib (LY2606368) is a small molecule checkpoint kinase inhibitor, mainly active against CHEK1, with minor activity against CHEK2. This causes induction of DNA double-strand breaks resulting in apoptosis. It was developed by Eli Lilly but the company announced in 2019 it was dropping prexasertib from active development, although clinical trials continue. Research continues into the efficacy of prexasertib in treatment of
acute myeloid leukemia, myelodysplastic syndrome, rhabdomyosarcoma, a
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/Prexasertib
date created:
date modified:
2023-08-02T11:55:30Z
main entity:
{"identifier":"Q27269284","url":"https://www.wikidata.org/entity/Q27269284"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/d/d8/Prexasertib.svg","width":1485,"height":970}
fields total:
13
integrity:
15