PP2 (kinase inhibitor)
id:
pp2-kinase-inhibitor-189-4220523
title:
PP2 (kinase inhibitor)
text:
PP2 is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100 μM) and JAK2 (50 μM). Despite its extensive use as a Src-selective inhibitor, recent research has shown that PP2 is non-selective and inhibits many other kinases with similar affinities.
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/PP2_(kinase_inhibitor)
date created:
2010-04-11T12:36:38Z
date modified:
2024-09-09T08:36:15Z
main entity:
{"identifier":"Q7120082","url":"https://www.wikidata.org/entity/Q7120082"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/c/c3/PP2_skeletal.svg","width":133,"height":208}
fields total:
13
integrity:
16