Phage-assisted continuous evolution
id:
phage-assisted-continuous-evolution-265-1681207
title:
Phage-assisted continuous evolution
text:
Phage-assisted continuous evolution (PACE) is a phage-based technique for the automated directed evolution of proteins. It relies on relating the desired activity of a target protein with the fitness of an infectious bacteriophage which carries the protein's corresponding gene. Proteins with greater desired activity hence confer greater infectivity to their carrier phage. More infectious phage propagate more effectively, selecting for advantageous mutations. Genetic variation is generated using
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Phage-assisted_continuous_evolution
date created:
date modified:
2024-01-06T00:00:10Z
main entity:
{"identifier":"Q104844626","url":"https://www.wikidata.org/entity/Q104844626"}
image:
fields total:
13
integrity:
13