PHA-543,613
id:
pha-543-613-284-2344552
title:
PHA-543,613
text:
PHA-543,613 is a drug that acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability. It is under development as a possible treatment for cognitive deficits in schizophrenia. It reduces excitotoxicity and protects striatal dopaminergic neurons in rat models. It also potentiates cognitive enhancement from memantine, decreases dynorphin release and inhibits GSK-B3.
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/PHA-543,613
date created:
date modified:
2024-03-25T04:19:49Z
main entity:
{"identifier":"Q76414815","url":"https://www.wikidata.org/entity/Q76414815"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/a/a0/PHA-543%2C613.svg","width":125,"height":52}
fields total:
13
integrity:
15