PF-4840154
id:
pf-4840154-320-650219
title:
PF-4840154
text:
PF-4840154 is a pyrimidine derivative discovered by Pfizer at its Sandwich, Kent research center. The compound is a potent, selective activator of both the human (EC50 = 23 nM) and rat (EC50 = 97 nM) TRPA1 channels. This compound elicits nociception in a mouse model through TRPA1 activation. PF-4840154 is used as a reference agonist of the TRPA1 channel for in-vitro high-throughput screening purposes, and is superior to allyl isothiocyanate for this use. The TRPA1 channel is considered an attrac
brand slug:
wiki
category slug:
encyclopedia
description:
Pyrimidine derivative chemical
original url:
https://en.wikipedia.org/wiki/PF-4840154
date created:
date modified:
2023-12-20T20:00:58Z
main entity:
{"identifier":"Q7119050","url":"https://www.wikidata.org/entity/Q7119050"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/c/c6/PF-4840154.svg","width":512,"height":229}
fields total:
13
integrity:
15