Oxyanion hole
id:
oxyanion-hole-306-17171946
title:
Oxyanion hole
text:
An oxyanion hole is a pocket in the active site of an enzyme that stabilizes transition state negative charge on a deprotonated oxygen or alkoxide. The pocket typically consists of backbone amides or positively charged residues. Stabilising the transition state lowers the activation energy necessary for the reaction, and so promotes catalysis. For example, proteases such as chymotrypsin contain an oxyanion hole to stabilise the tetrahedral intermediate anion formed during proteolysis and protect
brand slug:
wiki
category slug:
encyclopedia
description:
Pocket in the active site of an enzyme
original url:
https://en.wikipedia.org/wiki/Oxyanion_hole
date created:
date modified:
2022-02-27T12:15:25Z
main entity:
{"identifier":"Q7115108","url":"https://www.wikidata.org/entity/Q7115108"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/f/ff/Serine_protease_oxyanion_hole.png","width":730,"height":458}
fields total:
13
integrity:
15