OSI-7904
id:
osi-7904-296-7816895
title:
OSI-7904
text:
OSI-7904 is a noncompetitive liposomal thymidylate synthase inhibitor. OSI-7904 is a benzoquinazoline folate analog with antineoplastic activity. As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to thymidylate synthase, resulting in inhibition of thymine nucleotide synthesis and DNA replication. OSI-7904L is a liposome-encapsulated formulation of OSI-7904. Liposome encapsulation improves the efficacy and increases the half-life of OSI-7904. Its effect on solid tumors is curre
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/OSI-7904
date created:
date modified:
2023-04-05T23:24:05Z
main entity:
{"identifier":"Q7073016","url":"https://www.wikidata.org/entity/Q7073016"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/7/78/OSI-7904.svg","width":1140,"height":375}
fields total:
13
integrity:
15