Orthogonal ligand-protein pair
id:
orthogonal-ligand-protein-pair-289-15537047
title:
Orthogonal ligand-protein pair
text:
Orthogonal ligand-protein pairs are a protein-ligand binding pair made to be independent of the original binding pair. This is done by taking a mutant protein, which is activated by a different ligand. The intention here is that the orthogonal ligand will not interact with the original protein. The original protein will also be designed to not interact with the orthogonal ligand in certain cases. An example of orthogonal ligand-receptor interfaces are RASSL and DREADD. They are G protein-coupled
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wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Orthogonal_ligand-protein_pair
date created:
date modified:
2022-10-06T15:46:36Z
main entity:
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image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/f/fb/Myowndiagram2.png","width":1024,"height":1552}
fields total:
13
integrity:
14