North American Indian childhood cirrhosis
id:
north-american-indian-childhood-cirrhosis-300-14308454
title:
North American Indian childhood cirrhosis
text:
North American Indian childhood cirrhosis (NAIC) is a disease in humans that can affect Ojibway-Cree children in northwestern Quebec, Canada. The disease is due to an autosomal recessive abnormality of the UTP4 gene, which codes for cirhin, a nucleolar protein. NAIC is a ribosomopathy. An R565W mutation of UTP4 leads to partial impairment of cirhin interaction with NOL11. Initial transient neonatal jaundice advances over time to biliary cirrhosis with severe liver fibrosis. Eventually, liver fai
brand slug:
wiki
category slug:
encyclopedia
description:
A genetic pediatric liver disease
original url:
https://en.wikipedia.org/wiki/North_American_Indian_childhood_cirrhosis
date created:
date modified:
2024-01-05T20:44:10Z
main entity:
{"identifier":"Q25324164","url":"https://www.wikidata.org/entity/Q25324164"}
image:
fields total:
13
integrity:
14