Nef isocyanide reaction
id:
nef-isocyanide-reaction-303-9975011
title:
Nef isocyanide reaction
text:
The Nef isocyanide reaction is an addition reaction that takes place between isocyanides and acyl chlorides to form imidoyl chloride products, a process first discovered by John Ulrich Nef. The product imidoyl chloride can be hydrolyzed to give the amide, trapped with other nucleophiles, or undergo halide abstraction with silver salts to form an acyl nitrilium intermediate. The reaction is of some theoretical interest, as kinetic measurements and DFT studies have indicated that the addition occu
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Nef_isocyanide_reaction
date created:
date modified:
2023-06-19T08:40:19Z
main entity:
{"identifier":"Q56759817","url":"https://www.wikidata.org/entity/Q56759817"}
image:
fields total:
13
integrity:
13