Narasaka–Prasad reduction
id:
narasaka-prasad-reduction-317-1164039
title:
Narasaka–Prasad reduction
text:
The Narasaka–Prasad reduction, sometimes simply called Narasaka reduction, is a diastereoselective reduction of β-hydroxy ketones to the corresponding syn-dialcohols. The reaction employs a boron chelating agent, such as BBu2OMe, and a reducing agent, commonly sodium borohydride. This protocol was first discovered by Narasaka in 1984. The reaction proceeds through the 6-membered transition state shown below. Chelation by the boron agent favors hydride delivery from the top face because it leads
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wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Narasaka%E2%80%93Prasad_reduction
date created:
date modified:
2022-01-07T12:40:29Z
main entity:
{"identifier":"Q4371650","url":"https://www.wikidata.org/entity/Q4371650"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/6/63/Narasaka%E2%80%93Prasad_reduction_transition_state.png","width":633,"height":349}
fields total:
13
integrity:
14