MN-25
id:
mn-25-245-8811200
title:
MN-25
text:
MN-25 (UR-12) is a drug invented by Bristol-Myers Squibb, that acts as a reasonably selective agonist of peripheral cannabinoid receptors. It has moderate affinity for CB2 receptors with a Ki of 11 nM, but 22x lower affinity for the psychoactive CB1 receptors with a Ki of 245 nM. The indole 2-methyl derivative has the ratio of affinities reversed however, with a Ki of 8 nM at CB1 and 29 nM at CB2, which contrasts with the usual trend of 2-methyl derivatives having increased selectivity for CB2 (
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/MN-25
date created:
date modified:
2024-01-06T05:27:46Z
main entity:
{"identifier":"Q11163063","url":"https://www.wikidata.org/entity/Q11163063"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/4/4f/MN-25_structure.svg","width":630,"height":620}
fields total:
13
integrity:
15