Methylnitronitrosoguanidine
id:
methylnitronitrosoguanidine-305-7332869
title:
Methylnitronitrosoguanidine
text:
Methylnitronitrosoguanidine (MNNG or MNG, NTG when referred to colloquially as nitrosoguanidine) is a biochemical tool used experimentally as a carcinogen and mutagen. It acts by adding alkyl groups to the O6 of guanine and O4 of thymine, which can lead to transition mutations between GC and AT. These changes do not cause a heavy distortion in the double helix of DNA and thus are hard to detect by the DNA mismatch repair system. One of the earliest uses of methylnitronitrosoguanidine was in 1985
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/Methylnitronitrosoguanidine
date created:
date modified:
2023-07-02T03:25:37Z
main entity:
{"identifier":"Q12263499","url":"https://www.wikidata.org/entity/Q12263499"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/c/ce/MNNG_skeletal.png","width":674,"height":462}
fields total:
13
integrity:
15