Methyl-CpG-binding domain
id:
methyl-cpg-binding-domain-245-3830720
title:
Methyl-CpG-binding domain
text:
The Methyl-CpG-binding domain (MBD) in molecular biology binds to DNA that contains one or more symmetrically methylated CpGs. MBD has negligible non-specific affinity for unmethylated DNA. In vitro foot-printing with the chromosomal protein MeCP2 showed that the MBD could protect a 12 nucleotide region surrounding a methyl CpG pair. DNA methylation at CpG dinucleotides, the most common DNA modification in eukaryotes, has been associated with various phenomena such as alterations in chromatin st
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Methyl-CpG-binding_domain
date created:
date modified:
2024-01-04T21:07:14Z
main entity:
{"identifier":"Q24787964","url":"https://www.wikidata.org/entity/Q24787964"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/6/6a/Protein_MECP2_PDB_1qk9.png","width":621,"height":405}
fields total:
13
integrity:
14