Madelung synthesis
id:
madelung-synthesis-276-12241322
title:
Madelung synthesis
text:
In organic chemistry, Madelung synthesis is a chemical reaction that produces indoles by the intramolecular cyclization of N-phenylamides using strong base at high temperature. The Madelung synthesis was reported in 1912 by Walter Madelung, when he observed that 2-phenylindole was synthesized using N-benzoyl-o-toluidine and two equivalents of sodium ethoxide in a heated, airless reaction. Common reaction conditions include use of sodium or potassium alkoxide as base in hexane or tetrahydrofuran
brand slug:
wiki
category slug:
encyclopedia
description:
Organic chemical reaction for producing indoles
original url:
https://en.wikipedia.org/wiki/Madelung_synthesis
date created:
date modified:
2023-05-22T00:35:11Z
main entity:
{"identifier":"Q2632831","url":"https://www.wikidata.org/entity/Q2632831"}
image:
fields total:
13
integrity:
14