Locus suicide recombination
id:
locus-suicide-recombination-277-1342182
title:
Locus suicide recombination
text:
Locus suicide recombination (LSR) constitutes a variant form of class switch recombination that eliminates all immunoglobulin heavy chain constant genes. It thus terminates immunoglobulin and B-cell receptor (BCR) expression in B-lymphocytes and results in B-cell death since survival of such cells requires BCR expression. This process is initiated by the enzyme activation-induced deaminase upon B-cell activation. LSR is thus one of the pathways that can result into activation-induced cell death
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Locus_suicide_recombination
date created:
date modified:
2023-10-07T04:34:09Z
main entity:
{"identifier":"Q60794214","url":"https://www.wikidata.org/entity/Q60794214"}
image:
fields total:
13
integrity:
13