Ligand efficiency
id:
ligand-efficiency-241-14098912
title:
Ligand efficiency
text:
Ligand efficiency is a measurement of the binding energy per atom of a ligand to its binding partner, such as a receptor or enzyme. Ligand efficiency is used in drug discovery research programs to assist in narrowing focus to lead compounds with optimal combinations of physicochemical properties and pharmacological properties. Mathematically, ligand efficiency (LE) can be defined as the ratio of Gibbs free energy (ΔG) to the number of non-hydrogen atoms of the compound: where ΔG = −RTlnKi and N
brand slug:
wiki
category slug:
encyclopedia
description:
Measure of a ligand's binding energy per atom
original url:
https://en.wikipedia.org/wiki/Ligand_efficiency
date created:
date modified:
2023-07-24T20:11:40Z
main entity:
{"identifier":"Q6545861","url":"https://www.wikidata.org/entity/Q6545861"}
image:
fields total:
13
integrity:
14