Lewis lung carcinoma
id:
lewis-lung-carcinoma-314-265380
title:
Lewis lung carcinoma
text:
Lewis lung carcinoma is a hypermutated Kras/Nras–mutant cancer with extensive regional mutation clusters in its genome. A tumor that spontaneously developed as an epidermoid carcinoma in the lung of a C57BL mouse. It was discovered in 1951 by Dr. Margaret Lewis of the Wistar Institute and became one of the first transplantable tumors. Thirty-three deleterious mutations are present in 30 cancer genes including Kras, Nras, Trp53, Dcc, and Cacna1d. Cdkn2a and Cdkn2b are biallelically deleted from t
brand slug:
wiki
category slug:
encyclopedia
description:
1951 mouse tumour still used in research
original url:
https://en.wikipedia.org/wiki/Lewis_lung_carcinoma
date created:
date modified:
2024-04-06T19:30:28Z
main entity:
{"identifier":"Q6537255","url":"https://www.wikidata.org/entity/Q6537255"}
image:
fields total:
13
integrity:
14