Leimgruber–Batcho indole synthesis
id:
leimgruber-batcho-indole-synthesis-170-9913968
title:
Leimgruber–Batcho indole synthesis
text:
The Leimgruber–Batcho indole synthesis is a series of organic reactions that produce indoles from o-nitrotoluenes 1. The first step is the formation of an enamine 2 using N,N-dimethylformamide dimethyl acetal and pyrrolidine. The desired indole 3 is then formed in a second step by reductive cyclisation. In the above scheme, the reductive cyclisation is effected by Raney nickel and hydrazine. Palladium-on-carbon and hydrogen, stannous chloride, sodium hydrosulfite, or iron in acetic acid are also
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wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Leimgruber%E2%80%93Batcho_indole_synthesis
date created:
2005-07-16T19:55:13Z
date modified:
2024-08-31T23:51:33Z
main entity:
{"identifier":"Q2390993","url":"https://www.wikidata.org/entity/Q2390993"}
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fields total:
13
integrity:
14