Lectka enantioselective beta-lactam synthesis
id:
lectka-enantioselective-beta-lactam-synthesis-269-9048197
title:
Lectka enantioselective beta-lactam synthesis
text:
Lectka and co-workers developed a catalytic, asymmetric method to synthesize β-lactams. Achiral ketenes and imines, in the presence of a chiral nucleophilic catalyst, are allowed to react to make β-lactams in high yields, enantioselectivities, and diastereoselectivities. The proton sponge acts as a base to deprotonate the α-proton to the carbonyl in order to generate the ketene. Cinchona alkaloids are readily available and relatively inexpensive natural products that have features making them us
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Lectka_enantioselective_beta-lactam_synthesis
date created:
date modified:
2020-12-02T22:29:40Z
main entity:
{"identifier":"Q6512404","url":"https://www.wikidata.org/entity/Q6512404"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/6/6e/Chiral_Nucleophile_Catalyst.png","width":453,"height":280}
fields total:
13
integrity:
14