Knorr quinoline synthesis
id:
knorr-quinoline-synthesis-296-12910946
title:
Knorr quinoline synthesis
text:
The Knorr quinoline synthesis is an intramolecular organic reaction converting a β-ketoanilide to a 2-hydroxyquinoline using sulfuric acid. This reaction was first described by Ludwig Knorr (1859–1921) in 1886 The reaction is a type of electrophilic aromatic substitution accompanied by elimination of water. A 1964 study found that with certain reaction conditions formation of a 4-hydroxyquinoline is a competing reaction. For instance, the compound benzoylacetanilide (1) forms the 2-hydroxyquinol
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Knorr_quinoline_synthesis
date created:
date modified:
2024-03-21T23:40:45Z
main entity:
{"identifier":"Q1059500","url":"https://www.wikidata.org/entity/Q1059500"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/f/f7/KnorrCyclization2007.svg","width":470,"height":246}
fields total:
13
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14