K-Ras(G12C) inhibitor 6
id:
k-ras-g12c-inhibitor-6-207-11516971
title:
K-Ras(G12C) inhibitor 6
text:
K-Ras(G12C) inhibitor 6 is an irreversible inhibitor of oncogenic K-Ras(G12C), subverting the native nucleotide preference to favour GDP over GTP. Its family of inhibitors allosterically control GTP affinity and effector interactions by fitting inside a "pocket", or binding site, of mutant K-Ras. It is the most frequently mutated oncogene. Investigators and pathologists previously thought that K-Ras is undruggable. However, Kevan M. Shokat and his colleagues, in the Howard Hughes Medical Institu
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/K-Ras(G12C)_inhibitor_6
date created:
2014-06-17T03:23:18Z
date modified:
2024-09-11T08:03:50Z
main entity:
{"identifier":"Q18386375","url":"https://www.wikidata.org/entity/Q18386375"}
image:
fields total:
13
integrity:
15