ITCH
id:
itch-288-8341247
title:
ITCH
text:
ITCH is a HECT domain–containing E3 ubiquitin ligase that is ablated in non-agouti-lethal 18H mice. Itchy mice develop a severe immunological phenotype after birth that includes hyperplasia of lymphoid and hematopoietic cells, and stomach and lung inflammation. In humans ITCH deficiency causes altered physical growth, craniofacial morphology defects, defective muscle development, and aberrant immune system function. The ITCH gene is located on chromosome 20 in humans. ITCH contains a C2 domain,
brand slug:
wiki
category slug:
encyclopedia
description:
Protein-coding gene in the species Homo sapiens
original url:
https://en.wikipedia.org/wiki/ITCH
date created:
date modified:
2024-04-03T07:11:13Z
main entity:
{"identifier":"Q18047255","url":"https://www.wikidata.org/entity/Q18047255"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/f/ff/Ideogram_human_chromosome_20.svg","width":474,"height":189}
fields total:
13
integrity:
15