ISRIB
id:
isrib-188-9095927
title:
ISRIB
text:
ISRIB is an experimental drug that reverses the effects of eIF2α phosphorylation with an IC50 of 5 nM. It was discovered in the laboratory of Peter Walter at University of California, San Francisco (UCSF) through a semi-automated screening of a large library of small molecules by Carmela Sidrauski, who decided to pursue research on it. It has been shown to inhibit eIF2α phosphorylation-induced stress granule (SG) formation. Since eIF2α phosphorylation is known to be involved in memory formation,
brand slug:
wiki
category slug:
encyclopedia
description:
Experimental drug that reverses integrated stress response
original url:
https://en.wikipedia.org/wiki/ISRIB
date created:
2013-06-15T09:14:48Z
date modified:
2024-09-08T19:41:51Z
main entity:
{"identifier":"Q15409421","url":"https://www.wikidata.org/entity/Q15409421"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/d/da/ISRIB_structure.png","width":1688,"height":602}
fields total:
13
integrity:
16