Hypophosphatasia
id:
hypophosphatasia-173-15917429
title:
Hypophosphatasia
text:
Hypophosphatasia is a rare, and sometimes fatal, inherited metabolic bone disease. Clinical symptoms are heterogeneous, ranging from the rapidly fatal, perinatal variant, with profound skeletal hypomineralization, respiratory compromise or vitamin B6 dependent seizures to a milder, progressive osteomalacia later in life. Tissue non-specific alkaline phosphatase (TNSALP) deficiency in osteoblasts and chondrocytes impairs bone mineralization, leading to rickets or osteomalacia. The pathognomonic f
brand slug:
wiki
category slug:
encyclopedia
description:
Medical condition
original url:
https://en.wikipedia.org/wiki/Hypophosphatasia
date created:
2005-09-01T11:19:06Z
date modified:
2024-09-02T13:02:30Z
main entity:
{"identifier":"Q1313510","url":"https://www.wikidata.org/entity/Q1313510"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/0/04/1ALK.png","width":1440,"height":1080}
fields total:
13
integrity:
16