HOTTIP
id:
hottip-294-5962392
title:
HOTTIP
text:
In molecular biology, HOTTIP is a long non-coding RNA. The gene encoding HOTTIP is located at the 5′ tip of the HOXA locus, and coordinates the activation of several of the 5′ HOXA genes. The non-coding RNA is brought into close proximity with the HOXA genes by chromosomal looping. HOTTIP binds to the WDR5 protein, which forms a complex with the histone methyltransferase protein MLL. This targets the WDR5-MLL complex to the HOXA region and results in H3K4 methylation and transcriptional activati
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/HOTTIP
date created:
date modified:
2023-08-28T19:31:09Z
main entity:
{"identifier":"Q17125763","url":"https://www.wikidata.org/entity/Q17125763"}
image:
fields total:
13
integrity:
13