Hereditary diffuse leukoencephalopathy with spheroids
id:
hereditary-diffuse-leukoencephalopathy-with-spheroids-319-4550747
title:
Hereditary diffuse leukoencephalopathy with spheroids
text:
Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is a rare adult onset autosomal dominant disorder characterized by cerebral white matter degeneration with demyelination and axonal spheroids leading to progressive cognitive and motor dysfunction. Spheroids are axonal swellings with discontinuous or absence of myelin sheaths. It is believed that the disease arises from primary microglial dysfunction that leads to secondary disruption of axonal integrity, neuroaxonal damage, and focal
brand slug:
wiki
category slug:
encyclopedia
description:
Medical condition
original url:
https://en.wikipedia.org/wiki/Hereditary_diffuse_leukoencephalopathy_with_spheroids
date created:
date modified:
2024-03-27T01:58:50Z
main entity:
{"identifier":"Q5737835","url":"https://www.wikidata.org/entity/Q5737835"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/4/4e/Autosomal_dominant_-_en.svg","width":738,"height":1260}
fields total:
13
integrity:
15