Haploinsufficiency
id:
haploinsufficiency-197-14141399
title:
Haploinsufficiency
text:
Haploinsufficiency in genetics describes a model of dominant gene action in diploid organisms, in which a single copy of the wild-type allele at a locus in heterozygous combination with a variant allele is insufficient to produce the wild-type phenotype. Haploinsufficiency may arise from a de novo or inherited loss-of-function mutation in the variant allele, such that it yields little or no gene product. Although the other, standard allele still produces the standard amount of product, the total
brand slug:
wiki
category slug:
encyclopedia
description:
Concept in genetics
original url:
https://en.wikipedia.org/wiki/Haploinsufficiency
date created:
date modified:
2024-02-09T01:44:18Z
main entity:
{"identifier":"Q852654","url":"https://www.wikidata.org/entity/Q852654"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/8/84/Haploinsufficiency_graph_only.jpg","width":1041,"height":913}
fields total:
13
integrity:
15