Glutamate–cysteine ligase
id:
glutamate-cysteine-ligase-323-18458391
title:
Glutamate–cysteine ligase
text:
Glutamate–cysteine ligase (GCL) EC 6.3.2.2), previously known as γ-glutamylcysteine synthetase (GCS), is the first enzyme of the cellular glutathione (GSH) biosynthetic pathway that catalyzes the chemical reaction: L-glutamate + L-cysteine + ATP ⇌ γ-glutamyl cysteine + ADP + Pi GSH, and by extension GCL, is critical to cell survival. Nearly every eukaryotic cell, from plants to yeast to humans, expresses a form of the GCL protein for the purpose of synthesizing GSH. To further highlight the crit
brand slug:
wiki
category slug:
encyclopedia
description:
Enzyme in glutathione biosynthesis
original url:
https://en.wikipedia.org/wiki/Glutamate%E2%80%93cysteine_ligase
date created:
date modified:
2023-08-26T14:17:31Z
main entity:
{"identifier":"Q908460","url":"https://www.wikidata.org/entity/Q908460"}
image:
fields total:
13
integrity:
14