Genome-wide CRISPR-Cas9 knockout screens
id:
genome-wide-crispr-cas9-knockout-screens-235-17493447
title:
Genome-wide CRISPR-Cas9 knockout screens
text:
Genome-wide CRISPR-Cas9 knockout screens aim to elucidate the relationship between genotype and phenotype by ablating gene expression on a genome-wide scale and studying the resulting phenotypic alterations. The approach utilises the CRISPR-Cas9 gene editing system, coupled with libraries of single guide RNAs (sgRNAs), which are designed to target every gene in the genome. Over recent years, the genome-wide CRISPR screen has emerged as a powerful tool for performing large-scale loss-of-function
brand slug:
wiki
category slug:
encyclopedia
description:
Research tool in genomics
original url:
https://en.wikipedia.org/wiki/Genome-wide_CRISPR-Cas9_knockout_screens
date created:
date modified:
2023-12-03T23:47:07Z
main entity:
{"identifier":"Q96379172","url":"https://www.wikidata.org/entity/Q96379172"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/en/a/a4/Genome-wide_CRISPR_screen_-_Overview.png","width":959,"height":540}
fields total:
13
integrity:
15