Gassman indole synthesis
id:
gassman-indole-synthesis-197-15664938
title:
Gassman indole synthesis
text:
The Gassman indole synthesis is a series of chemical reactions used to synthesize substituted indoles by addition of an aniline and a ketone bearing a thioether substituent. This is a one-pot chemical reaction, and none of the intermediates are isolated. R1 can be hydrogen or alkyl, while R2 works best with aryl, but can also be alkyl. Electron-rich anilines, such as 4-methoxyaniline, tend to fail in this reaction. The 3-position thiomethyl group is often removed using Raney nickel to give the 3
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wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Gassman_indole_synthesis
date created:
date modified:
2024-03-27T20:49:07Z
main entity:
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image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/2/2b/Gassman_Indole_Synthesis_Summary.png","width":1178,"height":430}
fields total:
13
integrity:
14