Gapmer
id:
gapmer-318-3385136
title:
Gapmer
text:
Gapmers are short DNA antisense oligonucleotide structures with RNA-like segments on both sides of the sequence. These linear pieces of genetic information are designed to hybridize to a target piece of RNA and silence the gene through the induction of RNase H cleavage. Binding of the gapmer to the target has a higher affinity due to the modified RNA flanking regions, as well as resistance to degradation by nucleases. Gapmers are currently being developed as therapeutics for a variety of cancers
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Gapmer
date created:
date modified:
2024-03-14T05:31:22Z
main entity:
{"identifier":"Q107571517","url":"https://www.wikidata.org/entity/Q107571517"}
image:
fields total:
13
integrity:
13