Gallagher–Hollander degradation
id:
gallagher-hollander-degradation-170-3406370
title:
Gallagher–Hollander degradation
text:
In the Gallagher–Hollander degradation (1946) pyruvic acid is removed from a linear aliphatic carboxylic acid yielding a new acid with two carbon atoms fewer. The original publication concerns the conversion of bile acid in a series of reactions: acid chloride (2) formation with thionyl chloride, diazoketone formation (3) with diazomethane, chloromethyl ketone formation (4) with hydrochloric acid, organic reduction of chlorine to methylketone (5), ketone halogenation to 6, elimination reaction w
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Gallagher%E2%80%93Hollander_degradation
date created:
2008-03-12T20:45:58Z
date modified:
2024-08-31T23:54:54Z
main entity:
{"identifier":"Q5518845","url":"https://www.wikidata.org/entity/Q5518845"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/c/c3/Gallagher-Hollander_Degradation.svg","width":736,"height":809}
fields total:
13
integrity:
15