G-CSF factor stem-loop destabilising element
id:
g-csf-factor-stem-loop-destabilising-element-199-8383167
title:
G-CSF factor stem-loop destabilising element
text:
The G-CSF factor stem-loop destabilising element (SLDE) is an RNA element secreted by fibroblasts and endothelial cells in response to the inflammatory mediators interleukin-1 (IL-1) and tumour necrosis factor-alpha and by activated macrophages. The synthesis of G-CSF is regulated both transcriptionally and through control of mRNA stability. In unstimulated cells G-CSF mRNA is unstable but becomes stabilised in response to IL-1 or tumour necrosis factor alpha, and also in the case of monocytes a
brand slug:
wiki
category slug:
encyclopedia
description:
RNA element
original url:
https://en.wikipedia.org/wiki/G-CSF_factor_stem-loop_destabilising_element
date created:
date modified:
2023-12-02T21:28:16Z
main entity:
{"identifier":"Q5511884","url":"https://www.wikidata.org/entity/Q5511884"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/9/94/RF00183.jpg","width":452,"height":452}
fields total:
13
integrity:
15