Fosmidomycin
id:
fosmidomycin-245-2966600
title:
Fosmidomycin
text:
Fosmidomycin is an antibiotic that was originally isolated from culture broths of bacteria of the genus Streptomyces. It specifically inhibits DXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. It is a structural analogue of 2-C-methyl-D-erythrose 4-phosphate. It inhibits the E. coli enzyme with a KI value of 38 nM (4), MTB at 80 nM, and the Francisella enzyme at 99 nM. Several mutations in the E. coli DXP reductoisomerase were found to confer resistance
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/Fosmidomycin
date created:
date modified:
2023-12-03T00:21:10Z
main entity:
{"identifier":"Q905038","url":"https://www.wikidata.org/entity/Q905038"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/8/89/Fosmidomycin_.svg","width":512,"height":204}
fields total:
13
integrity:
15